Genetic disruption of skin development and differentiation is responsible for diseases that affect >20% of the population. We study the human skin in the laboratory and in the clinic. In the lab, we use primary skin cells, regenerated human epidermal tissue, and xenograft models to decipher the molecular pathways critical to epidermal development and homeostasis. In the clinic, we investigate the molecular pathogenesis of genetic skin diseases. Our goal is to integrate laboratory and patient-oriented approaches to gain insight to the form and function of skin in health and disease.
We are always open to new research directions. Our current interests include:
• Investigating non-protein coding genomic elements in epithelial homeostasis and disease with a focus on long non-coding RNAs (lncRNAs).
• Discovering new disease-associated genetic mutations and understanding their molecular mechanisms.
• Understanding the genetic and epigenetic impacts of medications on the skin and learning how this modifies treatment response and side effects.