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Overview

Skin Biology Research @ UC Irvine

UC Irvine’s skin biology community brings together investigators across Dermatology, Biological Chemistry, Microbiology and Molecular Genetics, Developmental and Cell Biology, Pharmacology, Engineering, and Computer Science. This cross-departmental structure has created a uniquely collaborative research environment focused on cutaneous biology, disease mechanisms, and translational discovery. For residents who seek a career that integrates science and medicine, UCI offers the resources of a large research enterprise with the mentorship and cohesion of a focused program.

 

UCI is one of only a small number of dermatology programs nationwide to hold both a NIAMS T32 Research Training Grant and a P30 Skin Cancer Center Grant, as well as access to the UCI K12 Mentored Career Development Program that provides structured support for early-stage physician-scientists transitioning to faculty roles.  These awards reflect institutional strength in skin research and faculty development that provide a robust platform and resources for physician-scientists, including access to cores, career resources, seed funding, interdisciplinary mentorship, and structured research training.

 

Our program is designed to support residents who aim to build an academic career through scientific inquiry, innovation, and patient-focused discovery. Trainees benefit from individualized mentorship, exposure to diverse investigative approaches, and a culture that encourages collaboration over competition. The result is a training environment where residents will grow as clinicians and researchers while developing the skills and independence needed for long-term success in academic dermatology.

Faculty

Faculty                                         Position                                                                       Research Interests    

Faculty in Skin Biology

Kristen Kelly, MD        Chair and Professor, Dermatology       Vascular biology, lasers, imaging

Bogi Andersen, PhD       Professor, Biological Chemistry        Circadian biology, differentiation

Xing Dai, PhD            Professor, Biological Chemistry        Stem cell biology

Maksim Plikus, PhD       Professor, Developmental Bio           Stem cells, hair follicle biology

Anand Ganesan, MD PhD    Professor, Dermatology                 Melanocyte biology and pigmentation

Scott Atwood, PhD        Professor, Developmental Bio           Skin cancer biology

Qing Nie, PhD            Professor, Mathematics                 Computational systems biology

Bryan Sun, MD PhD        Assoc Professor, Dermatology           Genetics and genomics of skin disease

Natasha Mesinkovska,     Assoc Professor, Dermatology           Alopecias and clinical trials

   MD PhD

Mihaela Balu, PhD        Assoc Professor, Dermatology           Biophotonics, clinical imaging

Michelle Min, MD         Asst Professor, Dermatology            Autoimmune diseases, clinical trials

Jessica Shiu, MD PhD     Asst Professor, Dermatology            Vitiligo and pigmentation biology

Nir Drayman, PhD         Asst Professor, Molecular Biology      HSV infections

Lauren Albricht, PhD     Asst Professor, Pharm Sci              Proteostasis and metabolism

Dae Seok Eom, PhD        Asst Professor, Developmental Bio      Intercellular communication

Piotr Konieczny, PhD     Asst Professor, Developmental Bio      Immunology and regenerative medicine

Publications

UC Irvine skin biology investigators publish across leading journals in skin biology, immunology, genomics, and clinical/translational dermatology. Our faculty’s work spans basic discovery through clinical and population-based research, reflecting the breadth of our scientific expertise and its impact on the field. Below is a selection of representative publications from the past few years:

• Arora-Min J, Padhiyar J, et al. Characterization of scalp involvement in dermatomyositis based on myositis-specific antibody subsets. J Am Acad Dermatol. 2024. [PDF]

• Cheng B, Peng SI, Jia YY, Tong E, Atwood SX, Sun BK. Comprehensive secretome profiling and CRISPR screen identifies SFRP1 as a key inhibitor of epidermal progenitor proliferation. Cell Death Dis. 2025. [PDF]

• Dragan M, Chen Z, Li Y, et al. Ovol1/2 loss–induced epidermal defects elicit skin immune activation and alter global metabolism. EMBO Rep. 2023. [PDF]

• Duan J, Ngo MN, Karri SS, et al. tauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data. Nat Commun. 2024. [PDF]

• Elsanadi RA, Messele F, Lee J, Choi B, Kelly KM. Optical coherence tomography–measured blood vessel characteristics of port-wine birthmarks by depth: a cross-sectional study. J Am Acad Dermatol. 2024. [PDF]

• Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell–cell communication using CellChat. Nat Commun. 2021. [PDF]

• Jin S, Plikus MV, Nie Q. CellChat for systematic analysis of cell–cell communication from single-cell transcriptomics. Nat Protoc. 2024. [PDF]

• King B, Ko J, Kwon O, et al. Baricitinib withdrawal and retreatment in patients with severe alopecia areata: the BRAVE-AA1 randomized clinical trial. JAMA Dermatol. 2024. [PDF]

• Ramos R, Pham KT, Prince RC, et al. Superstable lipid vacuoles endow cartilage with its shape and biomechanics. Science. 2025. [PDF]

• Shiu J, Zhang L, Lentsch G, et al. Multimodal analyses of vitiligo skin identify tissue characteristics of stable disease. JCI Insight. 2022. [PDF]

• Wang Y, Nguyen T, He Q, et al. Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish. eLife. 2024. [PDF]

• Wang X, Ramos R, Phan AQ, et al. Signalling by senescent melanocytes hyperactivates hair growth. Nature. 2023. [PDF]

• Wiedemann J, Billi AC, Bocci F, et al. Differential cell composition and split epidermal differentiation in human palm, sole, and hip skin. Cell Rep. 2023. [PDF]

• Xiao H, Shiu J, Chen CF, et al. Uncovering minimal pathways in melanoma initiation. Nat Commun. 2025. [PDF]

Publications

Funding & Resources

Funding and Resources

UC Irvine’s skin research community is supported by strong and diversified NIH funding, reflecting our national impact in cutaneous biology, cancer, inflammation, and regenerative medicine. For fiscal year 2025, our faculty in skin biology were the principal investigators for NIH grants totaling $9.8 million in funding, with additional $2.5 million in foundation and industry supported grants. This funding base sustains a research environment with robust infrastructure, collaborative opportunities, and stable support for long-term scientific growth.

 

UCI is one of only a few institutions with three major NIH mechanisms that directly support dermatology research and training:

 

• T32 Research Training Grant

Provides structured research training, career development programming, and dedicated support for residents and postdoctoral trainees. The T32 supports protected research time, grant-writing workshops, individualized mentoring committees, and pathways to develop a sustained research focus during residency and fellowship.

 

• P30 Skin Cancer Center Grant

Supports shared resources and research cores, interdisciplinary pilot funding, seminar series, and visiting professor programs. Trainees benefit from access to advanced technologies (genomics, imaging, bioinformatics, and tissue cores), as well as a collaborative scientific community that spans multiple departments and schools.

 

• K12 Mentored Career Development Program

Supports the transition from trainee to junior faculty by supporting protected research time, formal career development activities, and mentored research support. This mechanism helps promising physician-scientists bridge the critical and vulnerable early-faculty phase, establish funding, and launch an independent research trajectory.

 

Our programs provide a comprehensive ecosystem of support from residency through independence, designed to help physician-scientists build impactful academic careers. 

Education and Training

UC Irvine offers a structured and supportive physician-scientist pathway that integrates research training with world-class clinical education. Our goal is to help residents establish a strong scientific foundation early, develop a focused project during residency, and transition seamlessly into a productive postdoctoral and early faculty phase.

 

 

 

Early Mentorship and Planning (PGY-2 / Year 1 of Dermatology Residency)

Residents meet with program leadership and are paired with a research mentor during their first year. Together, they explore research interests, identify potential laboratory mentors, and develop an individualized training plan that aligns with long-term career goals.

 

Research Preparation and Skill-Building (PGY-3 / Year 2)

Residents receive six weeks of elective time to refine their project concept and prepare for active investigation. This period is used to meet with mentors, write IRB protocols, pursue pilot or seed grant funding, develop feasibility data, and build the foundation for a successful research phase.

 

Dedicated Research Immersion (PGY-4 / Year 3)

Residents may devote up to six months of protected laboratory time to launch their research project in earnest, supported by their mentor and a structured oversight committee. This phase emphasizes productivity, data generation, and positioning the resident for competitive fellowship, postdoctoral, or career development opportunities.

 

Research Development + Attending Role (PGY-5+)

Following residency, physician-scientist trainees transition into an attending physician role with 1–2 half-days of clinic and the remainder protected for research. Funding may be supported by the NIH T32, other institutional mechanisms, or individual awards (such as F32 or foundation grants), with the goal of building momentum toward independence.

Trainees prepare for and transition onto K08, K01, or K12 career development awards, benefiting from extensive institutional support for grant writing, career development, and mentorship. The program’s structure is designed to produce competitive applicants for early-stage faculty positions and independent research programs.

 

Training Ecosystem and Professional Development

Education is enhanced by the rich training environment supported by the T32, P30, and K12 programs, including:

 

  • Research-in-progress seminars and invited lectures

  • Grant writing workshops and mentoring committees

  • ICTS programs for clinical and translational research

  • Human subjects research education and IRB support

  • Access to institutional grants, cores, and pilot funding

  • Interdisciplinary journal clubs and trainee networking events

 

Together, these opportunities create a comprehensive, longitudinal pathway that supports physician-scientists from residency through early faculty positions.

UCI_Research Track.jpeg

Why UCI Dermatology?

UC Irvine is one of the best-kept secrets in academic dermatology. It is a place where high-quality research, true interdisciplinary collaboration, and personalized mentorship come together to support meaningful discovery. If you want an environment that will support your curiosity, amplify your potential, and help you build a lasting impact in our field, UC Irvine is an exceptional place to be!

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